![]() There are multiple pseudogenes of this gene. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Class II molecules are expressed in antigen presenting cells. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. Symbol HLA-DRB3 provided by HGNC Officialįull Name major histocompatibility complex, class II, DR beta 3 provided by HGNC Primary source HGNC:HGNC:4951 See related MIM:612735 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo Also known as DRB3 HLA-DPB1 HLA-DR1B HLA-DR3B HLA-DRB3* Summary HLA-DRB3 belongs to the HLA class II beta chain paralogues.
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